2023年，美国新政府所推行的“人类清除计划”迎来了第六个年头。剑走偏锋的极端政策，旨在抑制持续上升的失业率和犯罪率，在此期间却也有越来越多的无辜之人遇害，而富人们则斟好杯中酒，脑满肠肥欣赏甚至以看似高贵优雅的姿态参与一年一度的屠杀狂欢。在大屠杀即将开始之际，面临分手的情侣谢恩（Zach Gilford 饰）和莉兹（Kiele Sanchez 饰）的车在路上抛锚，他们慌乱不安地寻找藏身之地。刚刚失去最重要亲人的伊娃（Carmen Ejogo 饰）及其女儿卡莉（Zo? Soul 饰）躲在家中亦难免厄运临头，关键时刻母女被逡巡在城市巷尾的中士（弗兰克?格里罗 Frank Grillo 饰）救下，与此同时谢恩和莉兹也阴差阳错搭上了中士的车。 新仇旧恨以及对世界的各种愤懑不满，在这个夜晚集中爆发，脆弱的生命面临最惨烈的考验……
Follow a mad Chilean scientist's deadly virus escape the lab on contaminated currency worldwide: a thief steals contaminated notes in Italy; a Kosovo patient is infected in extreme surgeries; a German father is desperate to save his son.
In desperate debt to their volatile drug dealer, best friends Denise and Johnny agree to a sketchy job to pay off their last hit - breaking into a decrepit stash house to steal a bag of mysterious drugs. But whilst getting into the house may be easy, escape proves more troublesome, as the pair find themselves trapped inside with a deranged fiend. With no way out and not one to ...
