影片讲述了许倩（麦杉杉 饰）为了弄清好友林丽丽（刘洛 饰）在闹鬼大厦离奇死亡的原因，她入职了好友林丽丽生前所在的公司，却被意外卷入一场大厦闹鬼的诡异事件之中，渐渐揭开几十年的死亡诅咒。
民国时期，女警探芸曼为查辖区内两起离奇命案，假扮探亲女子来到湘西梧桐村，夜行山路时遇诡异纸船与赶尸人 还结识奎爷，二人同行并立下"三不"规矩。进村后，村中处处诡异，村民安伯邀他们住祠堂。芸曼察觉安伯言辞闪烁，傻子王二狗见她发狂。得知村中渔夫乔三，瓦匠陈四惨死且乔三尸体失踪，村民传是行尸索命。奎爷和芸曼查得玲玉曾被乔三，陈四，安伯等人以"祭洞神"之名活埋，而玲玉父亲水师傅是湘西赶尸 人，他伪装"行尸索命"为女复仇，害死乔三，陈四，安伯。最终，水师傅启动山洞机关欲同归于尽，却在山洞崩塌时救了芸曼，自己身亡。曼与奎爷站在玲玉坟前，感叹正义永存。
Since the death of their father and mother, Ambar and Dika move to a nursing home owned by their parents' best friend and their son, Agus. There are three people in the nursing home of Masa Toea: Grandma Ani, Grandpa Farid, and Oma Ida. The three are taken care of by Rina, a nurse who is also Agus's girlfriend. Not long after Ambar and Dika's move, Oma Ida's grandson, Arthur, comes to celebrate Eid. Ambar, who has the ability to see mystical things, accidentally gets a vision from the past: Ivanna, a Dutch woman, was tortured by Japanese soldiers which resulted in losing her head. A series of mystical events begin to haunt Ambar and all the residents of the nursing home, especially after they find a headless statue in the basement along with a vinyl record containing a scary song. On the day of Eid, things got even more tense when the residents of the orphanage found that Granny Ani has died without a head. Everyone panicky, especially when one by one the mystery of Ivanna's revenge is revealed. With the safety of all the residents of the orphanage now in danger, Ambar is required to finish Ivanna's revenge, before the spirit takes their lives.
