When, at the beginning of Deus Irae, Father Javier stares at a crucifix, his expressions and his hands suggest that the nerves are consuming him. A flashback reveals that this priest devotes his life to visiting families that claim to have seen things that do not belong to this world and cleansing their homes from the demons that try to possess them. But, upon returning to those houses, he notices that the evidence is always destroyed. This way, he discovers that a clan is after him, and must decide whether to hide from them or join them. In times when horror cinema tends to fall into the hands of directors that seek to build narratives that are introspective and close to reality, Pedro Cristiani goes back to old-school horror, where gore and the physical experience are above any other kind of feeling. A cinema that places the camera in front of the faces of the bloodiest demons and, instead of giving logic to them, chooses to face them whatever the cost.
卢修女早已失去信仰，她登上从蒙特利尔开往纽约的高速列车，同行的还有经验丰富的诺瓦克神父。列车行驶途中，一股强大的恶魔力量附身乘客，邪物化身阿斯蒙蒂斯让列车失控，朝着毁灭的方向疾驰。封闭车厢内，乘客接连被附身，危机层层蔓延。没有退路也没有外援，陆修女必须直面破碎的信仰，在失控的列车上，为被附身的乘客执行驱魔仪式，对抗不断扩散的邪恶，阻止这场列车上的死亡灾难。
影片讲述了因不明感染事件而被封锁的建筑内，孤立无援的幸存者们对抗以无法预测形态进化的感染者的故事。
遭受极度创伤的受害者被邀请参加一个集体治疗会议，在一个安全的环境中分享他们的经历。但随着他们讲述自己的故事，一个令人不安的真相逐渐显现出来，他们可能都在不幸中有着某种联系。
家族女族长哈丽雅特在95岁母亲离世后突发怪病，言行癫狂诡异，状态每况愈下。四个早已疏远的子女接到消息，纷纷赶回老宅照料。旧日的积怨与隔阂在同一屋檐下不断发酵，随着母亲的状态愈发反常，兄妹四人逐渐意识到，眼前的病症绝非普通的老年痴呆。尘封的家族秘密被一点点揭开，被唤醒的远古邪灵寄居在母亲体内，以复仇的姿态向子女们步步紧逼，整座老宅彻底沦为被诅咒的囚笼。
