Four college students venture to a storied haunted house over night. The goal is simple, obtain research for a paper they are writing on urban myths and legends. A caretaker, played by Richard Grieco, greets them and offers to share the tale of the home's tragic beginnings. As events unfold, the group starts to understand there's more to the stories than they first believed. Friendships and motives are questioned. The gentle caretaker's role is brought into questions. When tragedy strikes, they finally understand that Sanctus House is more than myth.
一种致命的“瘙痒症”病毒席卷城市，感染者会陷入疯狂抓挠直至自毁。丧偶父亲杰伊带着女儿躲进百货商店避难，却发现这里并非安全区。幸存者们因恐慌互相猜忌，物资短缺加剧矛盾，而商店内似乎还潜藏着未知威胁。杰伊必须在外部病毒与内部混乱的双重夹击下，保护女儿、对抗感染者，同时直面幸存者间的背叛与人性黑暗，在绝望中寻找生机。
濒临破产的遛狗师沃克，为摆脱经济困境，接下富豪客户道格在偏远庄园的特殊遛狗工作。他发现，这份工作的对象并非普通宠物，而是一个以犬类身份完全生活的男人。尽管初时不适，沃克仍为高薪妥协，却逐渐在扭曲的主从关系中，被步步侵蚀身份、控制感与人性边界，在生存压力与自我认同的拉扯中，陷入无法挣脱的诡异漩涡。
